New amphiphilic hyaluronan derivatives based on modification with alkenyl and aryl succinic anhydrides

Autor:	Birgitte M. Malle, Martin Mellergaard, Peter Skagerlind, Kristoffer Tømmeraas
Rok vydání:	2011
Předmět:	Polymers and Plastics Molecular mass Chemistry Aryl Organic Chemistry Succinic anhydride chemistry.chemical_compound Polymer chemistry Hyaluronic acid Amphiphile Materials Chemistry Proton NMR Organic chemistry Spectroscopy Two-dimensional nuclear magnetic resonance spectroscopy
Zdroj:	Carbohydrate Polymers. 85:173-179
ISSN:	0144-8617
Popis:	Hyaluronic acid (HA) of various molecular weights (4000, 14,000, 30,000, 100,000 and 850,000 g/mol) was modified with aryl and alkenyl succinic anhydrides (ASA). The modifications were conducted at pH 8.0–8.5 for 16 h at 25 or 60 °C. The 1H NMR spectrum of octenyl succinic anhydride modified HA (OSA-HA) was elucidated using 2D NMR (1H,1H g-COSY) spectroscopy. The modification was confirmed and the degree of substitution (DS) of 1.5–19% was determined using 1H NMR spectroscopy. Light scattering (SEC-MALLS-RI) showed that negligible degradation of HA had occurred during the modification procedure. Further, dynamic measurements of surface tension (γ) was done on 0.01–1% OSA-HA (Mw = 30,000 g/mol, DS = 19%) showing γ
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cb354b35f259aebdd4681bcaa5410520 https://doi.org/10.1016/j.carbpol.2011.02.011 Zobrazit plný text záznamu Full Text from ScienceDirect