Preparation and reactivity of sterically encumbered organocatalysts and their use in the preparation of ( S )-Pregabalin precursors
| Autor: | Mauro Cortigiani, Andrea Mereu, Alberto Tampieri, Mauro F. A. Adamo, Claudio Monasterolo |
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| Rok vydání: | 2017 |
| Předmět: |
Steric effects
Nitromethane biology 010405 organic chemistry Organic Chemistry Cinchona Fructose 010402 general chemistry biology.organism_classification 01 natural sciences Biochemistry 0104 chemical sciences chemistry.chemical_compound chemistry Drug Discovery Michael reaction Organic chemistry Ammonium Reactivity (chemistry) |
| Zdroj: | Tetrahedron Letters. 58:4205-4208 |
| ISSN: | 0040-4039 |
| DOI: | 10.1016/j.tetlet.2017.09.067 |
| Popis: | Herein we describe the preparation of a new class of sterically demanding organocatalysts derived from d -fructose and their use, alongside hitherto unreported doubly quaternarised Cinchona ammonium salts, in the Michael reaction of nitromethane with 4-nitro-5-alkenyl-isoxazoles. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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