Synthesis and evaluation of Lys 1 (α,γ-Folate)Lys 3 ( 177 Lu-DOTA)-Bombesin(1-14) as a potential theranostic radiopharmaceutical for breast cancer
| Autor: | Nallely Jiménez-Mancilla, Erika Azorín-Vega, Blanca Ocampo-García, Clara Santos-Cuevas, Liliana Aranda-Lara, Keila Isaac-Olivé, Guillermina Ferro-Flores, Flor de María Ramírez |
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| Rok vydání: | 2016 |
| Předmět: |
chemistry.chemical_classification
Oligopeptide Radiation Theranostic Nanomedicine business.industry Bombesin Peptide medicine.disease 030218 nuclear medicine & medical imaging 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Breast cancer chemistry 030220 oncology & carcinogenesis Cancer research medicine DOTA Molecular imaging Receptor Nuclear medicine business |
| Zdroj: | Applied Radiation and Isotopes. 107:214-219 |
| ISSN: | 0969-8043 |
| Popis: | The aim of this work was to synthesize Lys(1)(α,γ-Folate)-Lys(3)((177)Lu-DOTA)-Bombesin (1-14) ((177)Lu-Folate-BN), as well as to assess its potential for molecular imaging and targeted radiotherapy of breast tumors expressing folate receptors (FR) and gastrin-releasing peptide receptors (GRPR). Radiation absorbed doses of (177)Lu-Folate-BN (74 MBq, i.v.) estimated in athymic mice with T47D-induced breast tumors (positive to FR and GRPR), showed tumor doses of 23.9±2.1 Gy. T47D-tumors were clearly visible (Micro-SPECT/CT images). (177)Lu-Folate-BN demonstrated properties suitable as a theranostic radiopharmaceutical. |
| Databáze: | OpenAIRE |
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