Diuretic activity of methylxanthine derivative furoxane with one- and long-time use on the excretory function system of rats on the background of spontaneous diuresis

Autor:	I. V. Harkusha, E. A. Duchenko, M. V. Khomenko, O. V. Ponomarenko, V. I. Kornienko, E. V. Ladohubets
Rok vydání:	2020
Předmět:	medicine.medical_specialty Creatinine Chemistry medicine.medical_treatment media_common.quotation_subject Diuresis Urine Urination Natriuresis Excretion chemistry.chemical_compound Hydrochlorothiazide Endocrinology Internal medicine medicine Diuretic medicine.drug media_common
Zdroj:	Veterinary science, technologies of animal husbandry and nature management. :36-39
ISSN:	2663-5542 2617-8346
DOI:	10.31890/vttp.2020.06.06
Popis:	The study of the effect of furoxane on renal activity under conditions of spontaneous diuresis was performed by the method of Berkhin. Hydrochlorothiazide was chosen as a reference drug. Furoxane and hydrochlorothiazide were administered intragastrically at a dose of 25 mg/kg for 7 days. The content of Na+ and K+in the urine was determined by flame photometry. The concentration of creatinine in the urine was studied by the method of Folin in the modification of Berkhin. The obtained results were calculated using the methods of variation statistics. The analysis of the results shows that under one-time action of furoxane in rats the daily urination increased by 210.4 % (p
Databáze:	OpenAIRE
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