Solubility of ketoconazole in N-methyl-2-pyrrolidone + water mixtures at T = (293.2 to 313.2) K
| Autor: | Fleming Martínez, Taravat Ghafourian, Ayda Hatefi, Abolghasem Jouyban, Elaheh Rahimpour, Mohammad Barzegar-Jalali |
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| Rok vydání: | 2019 |
| Předmět: |
Enthalpy
Thermodynamics 02 engineering and technology 010402 general chemistry 01 natural sciences chemistry.chemical_compound symbols.namesake N-Methyl-2-pyrrolidone Materials Chemistry medicine Physical and Theoretical Chemistry Solubility Dissolution Spectroscopy Chemistry Atmospheric temperature range 021001 nanoscience & nanotechnology Condensed Matter Physics Atomic and Molecular Physics and Optics 0104 chemical sciences Electronic Optical and Magnetic Materials Gibbs free energy Solvent symbols Ketoconazole 0210 nano-technology medicine.drug |
| Zdroj: | Journal of Molecular Liquids. 281:150-155 |
| ISSN: | 0167-7322 |
| DOI: | 10.1016/j.molliq.2019.02.038 |
| Popis: | The aim of this investigation was to study the solubility behavior of ketoconazole in the binary mixed solvents of N-methyl-2-pyrrolidone (NMP) and water within the temperature range of 293.2–313.2 K and develop mathematical models using five cosolvency models; i.e. van't Hoff equation, Yalkowsky model, Jouyban-Acree model, Jouyban-Acree-van't Hoff model and modified Wilson model. In addition, density of the solutions saturated with ketoconazole in various solvent compositions and temperatures was measured and the results were correlated according to the Jouyban–Acree model. Moreover, apparent thermodynamic quantities of ketoconazole dissolution process in the NMP/water mixtures, including entropy, enthalpy and Gibbs free energy were computed using van't Hoff and Gibbs equations. The modeling showed that the mean relative deviation (MRD%) of the back-calculated solubility data using the above mentioned models were 2.9%, 55.4%, 13.6%, 8.6% and 21.8% respectively. |
| Databáze: | OpenAIRE |
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