Design of a Continuous Tubular Cooling Crystallizer for Process Development on Lab-Scale
| Autor: | Ramona Gorny, Kerstin Wohlgemuth, Oliver Klaas, Norbert Kockmann, Jonas Ahlert, Lukas Hohmann |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Air cooling
Engineering Plug flow 010405 organic chemistry business.industry General Chemical Engineering Flow (psychology) Nucleation Control engineering General Chemistry 010402 general chemistry Residence time distribution 01 natural sciences Unit operation Industrial and Manufacturing Engineering 0104 chemical sciences law.invention law Inverter Crystallization business Process engineering |
| Zdroj: | Chemical Engineering & Technology. 39:1268-1280 |
| ISSN: | 0930-7516 |
| DOI: | 10.1002/ceat.201600072 |
| Popis: | Continuous manufacturing of fine chemical, life science, and pharmaceutical products is under recent investigation in R&D. As cooling crystallization is an important unit operation for purification of products, continuously operated, scalable devices are required for process development on lab-scale. A tubular crystallizer was developed, based on the coiled flow inverter design. Experimental characterization proved a narrow residence time distribution of the liquid phase close to ideal plug flow. Counter-current air cooling allows for adjusting linear and curved temperature profiles. Unseeded operation with the L-alanine (water) system demonstrated that nucleation has to be actively controlled to successfully apply intensified continuous cooling crystallization processes. |
| Databáze: | OpenAIRE |
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