ChemInform Abstract: Synthesis of 4-Vinyl-Substituted β-Lactams of the Oxamazin Family

Autor:	Alberto Guaragna, Luca Banfi, Umberto Valcavi, Eva Baldaro, Enrica Narisano, Giuseppe Guanti
Rok vydání:	1988
Předmět:	Acylation chemistry.chemical_compound Hydroxylamine chemistry β lactams Side chain General Medicine Medicinal chemistry Ethyl glycinate Propiolaldehyde Adduct
Zdroj:	ChemInform. 19
ISSN:	0931-7597
DOI:	10.1002/chin.198844351
Popis:	4-Vinyl-substituted oxamazins 15,16, and 3 have been prepared. Key steps of the synthesis are: the preparation of protected α-amino-β-hydroxyacid 6 through ester enolate condensation of ethyl glycinate STABASE adduct 8 with CH-protected propiolaldehyde 9, the coupling of this acid with an appropriate protected hydroxylamine, the cyclization of resulting hydroxamate, and finally the acylation of the amino-group in 3 with ATMO side chain.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cb10868bf942965c1643ee86db838056 https://doi.org/10.1002/chin.198844351 Zobrazit plný text záznamu Plný text