| Popis: |
Background The effect of hormone replacement therapy (HRT) on colorectal cancer (CRC) mortality and all-cause mortality remains unclear. We conducted a systematic review and dose‒response meta-analysis to determine the effects of HRT on CRC mortality and all-cause mortality. Methods We searched the PubMed, Embase, and Cochrane Library electronic databases for all relevant studies published until June 2022 to investigate the effects of HRT exposure on survival rates for patients with CRC. Two reviewers independently extracted individual study data and evaluated THE risk of bias among the studies using the Newcastle‒Ottawa Scale. To examine a potential nonlinear relationship between the year of HRT use and CRC mortality, we performed a two-stage random effects dose‒response meta-analysis. RESULTS Ten cohort studies encompassing 480,628 individuals were included. The meta-analysis revealed that HRT was inversely associated with the risk of CRC mortality [hazard ratios (HR) = 0.77, 95% CI (0.68, 0.87), I2 = 69.5%, P 2 = 89.6%, p |
