Structure of 6-aminobenzofuran-2-sulfonamide: A tropically active carbonic anhydrase inhibitor

Autor:	B. Mazumdar, Gabriele Bocelli, S. K. Talapatra, M. Datta, S. K. Mazumdar, A. K. Das
Rok vydání:	1993
Předmět:	chemistry.chemical_classification Hydrogen bond General Chemistry Crystal structure Triclinic crystal system Dihedral angle Condensed Matter Physics Ring (chemistry) Sulfonamide chemistry.chemical_compound Crystallography chemistry Structural Biology Furan Benzofuran Spectroscopy
Zdroj:	Journal of Crystallographic and Spectroscopic Research. 23:519-522
ISSN:	1572-8854 0277-8068
DOI:	10.1007/bf01182530
Popis:	Crystals of the title compound are triclinic. Space groupP1,a=8.652(2),b=5.184(2),c=5.050(2)A,α=100.26(3)°,β=100.33(4)°, γ=72.82(3)°. The structure was solved by direct methods and refined by a full-matrix, least-squares procedure toR=0.033 for 1168 observed [I >2σ(I)] reflections. The sulfonamide group is at a right angle to the benzofuran ring and the dihedral angle between the benzene and furan ring is 2.0(1)°. In the crystal packing the molecules are linked together by N-H⋯O and N-H⋯N type hydrogen bonds arranging themselves in such a way that there are alternate hydrophobic and hydrophilic regions extended along the a-axis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cafe68aa185068b4d8acdf433ac4183c https://doi.org/10.1007/bf01182530 Zobrazit plný text záznamu Full text from SpringerLink