Scanning Magneto-Inductive Sensor for Quantitative Assay of Prostate-Specific Antigen
| Autor: | Montserrat Rivas, María Carmen Blanco-López, D. Lago-Cachón, Amanda Moyano, María Salvador, J.C. Martínez-García, Myriam Oliveira-Rodríguez, José Ángel Flores García |
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| Rok vydání: | 2017 |
| Předmět: |
Computer science
010401 analytical chemistry Nanotechnology 02 engineering and technology equipment and supplies 021001 nanoscience & nanotechnology 01 natural sciences Signal 0104 chemical sciences Electronic Optical and Magnetic Materials Magnetic field Electromagnetic induction Software portability Inductive sensor 0210 nano-technology human activities Electrical impedance Magneto Superparamagnetism Biomedical engineering |
| Zdroj: | IEEE Magnetics Letters. 8:1-5 |
| ISSN: | 1949-3088 1949-307X |
| DOI: | 10.1109/lmag.2017.2702108 |
| Popis: | Among analytical tests available for point-of-care diagnostics, the lateral flow immunoassay (LFIA) stands out for its low-cost, speed, portability, and ease of use. By its nature, this paper-based instrument is qualitative, intended to provide a positive/negative reading. LFIA, coupled to a quantitative readout device that did not compromise its advantages, would be a powerful tool for many clinical and biological applications. A promising enabling strategy is the use of superparamagnetic nanoparticles as labels. Their reduction of visual signal compared to gold or latex reporters is compensated by their magnetic induction, which enables absolute quantification with magnetic sensors. In this letter, a magnetic LFIA reader is presented that exploits spontaneous magnetic switching, a characteristic of superparamagnetism, to produce a quantifiable electromagnetic induction in an alternating current carrier. In contrast to other magnetic sensors, this approach does not require the application of external magnetic fields, which greatly reduces its complexity. The capability of the system for bioanalyte quantification has been proved by successfully measuring prostate-specific antigen levels in the interval of clinical interest. |
| Databáze: | OpenAIRE |
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