| Popis: |
Insulin is an anabolic hormone that plays a central role in glucose homeostasis. Synthesis, secretion and appearance of insulin in portal and peripheral circulation are complex and tightly regulated. As many of the tissues involved are not directly accessible, mathematical models have been developed to describe insulin kinetics. This paper presents a mathematical synthesis of models for the study of insulin kinetics and is meant as a supplemental to our recent review of glucose kinetics models, some of which encompass insulin sub-models. Models are described in steady and non-steady state and are grouped into compartmental and non-compartmental schemes. |
