| Autor: |
Kelly A. Crotty, Kimon Argyropoulos, Ana Rodriguez, Lawrence Hsu Lin, Huilin Li, Kun Qian, Marisol Zuniga, Paolo Cotzia, Claudia Gomes |
| Rok vydání: |
2021 |
| Předmět: |
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| DOI: |
10.1101/2021.01.04.20249054 |
| Popis: |
COVID-19 can lead to severe disease and death, however the mechanisms of pathogenesis in these patients remain poorly understood. High levels of autoimmune antibodies have been observed frequently in COVID-19 patients but their specific contribution to disease severity and clinical manifestations remain unknown.We performed a retrospective study of 115 COVID-19 hospitalized patients with different degrees of severity to analyze the generation of autoimmune antibodies to common antigens: a lysate of erythrocytes, the lipid phosphatidylserine (PS) and DNA.High levels of IgG autoantibodies against erythrocyte lysates were observed in a large percentage (up to 41%) of patients. Anti-DNA antibodies determined upon hospital admission correlated strongly with later development of severe disease, showing a positive predictive value of 89.5% and accounting for 22% of total severe cases. Statistical analysis identified strong correlations between anti-DNA antibodies and markers of cell injury, coagulation, neutrophil levels and erythrocyte size.Anti-DNA autoantibodies may play an important role in the pathogenesis of COVID-19 and could be developed as a predictive biomarker for disease severity and specific clinical manifestations. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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