Abstract 232: Vascular Dysfunction Induced By High Pressure Levels Is Mediated By Rac-1

Autor:	Carmine Vecchione, Maria Teresa Gentile, Alba Di Pardo, Umberto Bettarini, Giuseppe Lembo
Rok vydání:	2007
Předmět:	Physiology (medical) Cardiology and Cardiovascular Medicine
Zdroj:	Circulation. 116
ISSN:	1524-4539 0009-7322
DOI:	10.1161/circ.116.suppl_16.ii_26
Popis:	Oxidative stress plays a crucial role in the vascular dysfunction present in hypertension. The molecular mechanism involved are not completely elucidated. One of the principal source of oxidative stress at vascular level is the NADPH oxidase enzyme which needs Rac-1 to be activated. Aim of our study was to evaluate the role of Rac-1 in vascular dysfunction induced by high pressure levels. To test this hypothesis, carotid of mice were placed on pressure system and subjected to increasing levels of pressure (100 and 180 mmHg). In particular, after a period of perfusion (1h) with 100 mmHg vessels were subjected to 180 mmHg for three hours. At the end of perfusion period the vascular reactivity was tested. Our results demonstrate that vessels perfused with 180mmHg (n=8) showed an impaired vasorelaxation to acetylcholine as compared to vessels perfused with 100 mmHg (n=7) (% max vasorelaxation: 47±3 vs 88±7, p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cacaa8be7f873db1dd86c1dc8f1bd01b https://doi.org/10.1161/circ.116.suppl_16.ii_26 Zobrazit plný text záznamu