Leukocyte telomere length and hTERT genetic polymorphism rs2735940 influence the renal cell carcinoma clinical outcome
| Autor: | Joaquina Maurício, Rui Medeiros, Mariana Morais, Inês Nogueira, Jorge Alberto de Oliveira, Francisca Dias, Telma Resende, Ana Teixeira |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty business.industry Disease progression Single-nucleotide polymorphism General Medicine urologic and male genital diseases medicine.disease Telomere 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Prognosis biomarker Renal cell carcinoma 030220 oncology & carcinogenesis Internal medicine Genotype medicine Overall survival Telomerase reverse transcriptase business neoplasms |
| Zdroj: | Future Oncology. 16:1245-1255 |
| ISSN: | 1744-8301 1479-6694 |
| Popis: | Aim: Analysis of the genetic hTERT-1327 C>T (rs2735940) influence on leukocyte telomere length (LTL) and tumor development, progression and overall survival in renal cell carcinoma (RCC) patients. Materials & methods: Using leukocyte DNA of RCC patients and healthy individuals, LTL measurement and allelic discrimination of rs2735940 was performed by real-time PCR. Results: RCC patients showed shorter LTL than healthy individuals and LTL increased with clinical stage. CC+TC genotypes healthy carriers’ presented shorter LTL. However, no statistical association between the different genotypes and RCC risk. Nevertheless, CC homozygous presented a reduced time to disease progression and a lower overall survival. The use of hTERT-1327 single nucleotide polymorphism information increased the capacity to predict risk for RCC progression. Conclusion: In fact, in healthy individuals, hTERT-1327 CC+TC genotypes were associated with shorter LTL, and this single nucleotide polymorphism was associated with time to disease progression, being a promising potential prognosis biomarker to be used in the future. |
| Databáze: | OpenAIRE |
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