Comparing the protective effect of L-carnitine, chromium, and vitamin D with metformin on kidney parameters, lipid profiles, and antioxidant indices in streptozotocin-diabetic rats
| Autor: | Mohammad Adibnejad, Elham Tabatabaie, Parisa Sheikh Samani, Ali Noori, Kahin Shahanipour |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Vitamin
Type 1 diabetes medicine.medical_specialty endocrine system diseases business.industry Biomedical Engineering nutritional and metabolic diseases medicine.disease Streptozotocin Malondialdehyde Metformin chemistry.chemical_compound Endocrinology chemistry Internal medicine Diabetes mellitus medicine Vitamin D and neurology Pharmacology (medical) Carnitine General Pharmacology Toxicology and Pharmaceutics business medicine.drug |
| Zdroj: | Journal of Reports in Pharmaceutical Sciences. 8:128 |
| ISSN: | 2322-1232 |
| Popis: | Introduction: Type 1 diabetes mellitus is believed to be caused by decline of insulin secretion because of destruction of the pancreatic β cell, which is characterized with symptoms such as hyperglycemia, polyuria, polydipsia, weight loss, and other symptoms. Due to the lack of sufficient data about protective effect of L -carnitine, chromium, and vitamin D as compared with metformin on biochemical indices in streptozotocin-diabetic rats, it seems necessary to determine the effects of these medications on diabetes. Materials and Methods: Sixty Wistar rats were divided into 12 diabetic and healthy groups, and 10 groups of witness, metformin )150 mg/kg(, L -carnitine )200 mg/kg(, and chromium )2 mg/kg(, vitamin D (0.06 µg) and a group treated with simultaneous combined therapy of L -carnitine, chromium, and vitamin D. Diabetes mellitus was induced by streptozotocin. Rats with glucose levels of more than 300 mg/dL were considered as diabetic. After 30 days of treatment, the serum concentrations of renal parameters, lipid profile, malondialdehyde, and activity of superoxide dismutase were measured in the studied groups. Results: Malondialdehyde had a significant decrease in all diabetic groups but an increase in nondiabetic metformin and L -carnitine groups (P L -carnitine, chromium, and vitamin D (P L -carnitine, chromium treatment, and combined group showed a significant decrease (P L -carnitine, chromium, and vitamin D such as metformin seemed appropriate, which had the hypoglycemic, antilipidemic, and antioxidant effects. |
| Databáze: | OpenAIRE |
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