肾小球皮质密度对随访5年的IgA肾病不良预后的预测
| Autor: | Zhen-jie Chen, null 陈振杰, null 李航, null 蔡建芳, null 张鑫, null 李超, null 邹佩美, null 李明喜, null 陈丽萌, null 李雪梅, null 李学旺, null 文煜冰, Hang Li, Jian-fang Cai, Xin Zhang, Chao Li, Pei-mei Zou, Ming-xi Li, Li-meng Chen, Xue-mei Li, Xue-wang Li, Yu-bing Wen |
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| Rok vydání: | 2017 |
| Předmět: |
Prognostic factor
medicine.medical_specialty Proteinuria Proportional hazards model business.industry 030232 urology & nephrology Urology Renal function General Medicine Urine 030204 cardiovascular system & hematology medicine.disease Nephropathy 03 medical and health sciences 0302 clinical medicine Medicine medicine.symptom business Survival analysis |
| Zdroj: | Chinese Medical Sciences Journal. 32:145-151 |
| ISSN: | 1001-9294 |
| Popis: | Objective To investigate whether glomerular density (GD) could be an independent prognostic factor for patients of IgA nephropathy with estimated glomerular filtration rate (eGFR) of 30 to 60 ml/min per 1.73 m2, or for patients with time-average proteinuria Methods A total of 173 patients with biopsy-confirmed IgA nephropathy diagnosed from January 2000 to December 2010 were included. All of these patients were followed up for more than 5 years. The endpoint was a > 30% of decline in eGFR from baseline after 5-year follow-up. The optimal cut-off value of GD was calculated by ROC curve. Kaplan-Meier method and Cox regression analysis was used for survival analysis. Results A 30% of decline in eGFR occurred in 14.5% of all patients. The optimal diagnostic cut-off value of GD was 1.99/mm2 (AUC = 0.90, sensitivity = 84.0%, specificity = 81.8%) determined by ROC curve. The low GD group (GD Conclusion GD could be an independent prognostic factor for patients of IgA nephropathy with eGFR at 30 to 60 ml/min per 1.73 m2 of body surface, particularly for those with time-averaged amount of urine protein less than 0.5 g per day. |
| Databáze: | OpenAIRE |
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