Phase III comparison of the treatment of advanced gastrointestinal cancer with bolus weekly 5-FU vs. methyl-CCNU plus bolus weekly 5-FU.A southwest oncology group study

Autor: Vainutis K. Vaitkevicius, Laurence H. Baker, B. W. Ruffner, Edmund A. Gehan, Daniel E. Lehane, Ronald L. Stephens, Francis S. Morrison, Richard Matter, Stephen E. Jones, Talley Rw
Rok vydání: 1976
Předmět:
Zdroj: Cancer. 38:1-7
ISSN: 1097-0142
0008-543X
DOI: 10.1002/1097-0142(197607)38:1<1::aid-cncr2820380102>3.0.co;2-s
Popis: In a randomized and stratified study, 294 patients with advanced gastrointestinal cancer were treated either with 5-fluorouracil (5-FU) 400 mg/m2 weekly intravenously (i.v.) or 5-FU 400 mg/m2 i.v. weekly plus methyl-CCNU 175 mg/m2 orally (p.o.) every 6 weeks. The response rate in colorectal cancer with 5-FU was 9.5% while the two-drug treatment produced a response of 31.8% (p = .009). The response in all gastrointestinal cancers to 5-FU was 10.6% as compared with 29.3% for the combination (p = .012). All responses were partial. The two-drug regimen is more effective and more toxic than weekly 5-FU therapy.
Databáze: OpenAIRE
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