New synthesis of pyrido[4,3-b]indoles (γ-carbolines) on the basis of indolin-2-one lactim ether

Autor:	M. I. Evstratova, S. S. Kiselev, O. S. Anisimova, Vladimir G Granik, N. P. Solov'eva, T. V. Golovko, O. B. Smirnova
Rok vydání:	2008
Předmět:	Indole test chemistry.chemical_compound chemistry Acetal Dimethylformamide Organic chemistry Oxindole Ether General Chemistry Indolin 2 one Triethyl orthoformate Malononitrile
Zdroj:	Russian Chemical Bulletin. 57:177-185
ISSN:	1573-9171 1066-5285
DOI:	10.1007/s11172-008-0026-7
Popis:	Condensation of indolin-2-one (oxindole) lactim ether with malononitrile leads to 2-dicyanomethylidene-2,3-dihydroindole, the reaction of which with dimethylformamide diethyl acetal (or with triethyl orthoformate) and the subsequent cyclization afford 4-cyanopyrido[4,3- b]indoles (γ-carbolines). 3-Amino-4-cyanopyrido[4,3-b]indole was used in the synthesis of substituted pyrimido[4,5-c]-γ-carbolines.
Databáze:	OpenAIRE
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