Su1963 Cortical Thinning in Female Patients With Irritable Bowel Syndrome
| Autor: | Sam Hobel, Alex Genco, Paul M. Thompson, Zhiguo Jiang, Bahar Ebrat, Florian Kurth, Cody Ashe-McNalley, Arthur W. Toga, Alen Zamanyan, Jennifer S. Labus, Shantanu H. Joshi, Emeran A. Mayer, Craig Schwartz, Yonggang Shi, Ivo D. Dinov |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Ventrolateral prefrontal cortex Hepatology business.industry media_common.quotation_subject Gastroenterology Hippocampus Cognition Audiology medicine.disease medicine.anatomical_structure Endocrinology Internal medicine Cortex (anatomy) Perception Fixation (visual) Female patient medicine business Irritable bowel syndrome media_common |
| Zdroj: | Gastroenterology. 142:S-547 |
| ISSN: | 0016-5085 |
| Popis: | Background. Converging evidence suggests that increased attention to afferent signals from the gut plays an important role in the increased perceptual response to visceral stimuli reported in irritable bowel syndrome (IBS). We hypothesize that prefrontal circuitry controlling attention to threat-related stimuli is less efficient in IBS patients compared to healthy controls (HCs). Aims. To quantify and compare the efficiency of cognitive control regions underlying selective attention to threat-related stimuli between IBS patients and HCs, using a GI symptom unrelated paradigm. Methods. We measured brain response (Siemens 3 Tesla Trio MRI scanner) in 32 females (16 IBS patients, 16 HCs) during administration of the house face matching task, a cognitive task developed and validated to test selective attention to threatening stimuli as well as index processing of task-irrelevant threat stimuli. Subjects were presented with pictures of pairs of houses and faces (fearful or neutral) arranged in a vertical or horizontal orientation around a central fixation cross. During the task subjects were asked to match either houses or faces.. SPM8 was employed to preprocess and analyze the imaging data using the general linear model and a region of interest analysis examining cognitive control and emotional arousal regions. Results were considered significant at p |
| Databáze: | OpenAIRE |
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