Intra-operative assessment of tumor resection margins by Raman spectroscopy to guide oral cancer surgery (Conference Presentation)

Autor: Senada Koljenović, Yassine Aaboubout, Robert J. Baatenburg de Jong, Cees Meeuwis, Viacheslav Artyushenko, Eppo B. Wolvius, Iskander Usenov, Tom C. Bakker-Schut, Florence van Lanschot, Aniel Sewnaik, Elena Sokolova, Dominiek A. Monserez, Maria R Nunes Soares, Ivo ten Hove, Alexey Bocharnikov, Jose A. Hardillo, Hetty Mast, Martin J. G. van der Wolf, Stijn Keereweer, Elisa M. Barroso, Gerwin J. Puppels
Rok vydání: 2020
Předmět:
Zdroj: Biomedical Vibrational Spectroscopy 2020: Advances in Research and Industry.
DOI: 10.1117/12.2544394
Popis: In oral cavity cancer only 15% of operations succeed in removing the whole tumor with the required margin of more than 5 mm of surrounding healthy tissue. This negatively affects prognosis. Clearly the hands and eyes of the surgeon do not suffice. We use a fiber optic needle probe for high-wavenumber Raman spectroscopic analysis of the freshly resected tissue to determine if the distance between the resection surface and the tumor is sufficient. A system is under development to inspect the resected tissue in under 15 minutes, while the patient is still in the OR.
Databáze: OpenAIRE