Hyperuricemia and Cardiovascular Diseases in Very Elderly Patients with Coronary Artery Disease

Autor:	S. V. Topolyanskaya, A. E. Semashkova, O. N. Vakulenko, L. M. Kupina, L. I. Dvoretskiy
Rok vydání:	2019
Předmět:	medicine.medical_specialty business.industry nutritional and metabolic diseases Atrial fibrillation medicine.disease Gout Coronary artery disease chemistry.chemical_compound chemistry Internal medicine Heart failure medicine Uric acid Hyperuricemia Myocardial infarction business Stroke
Zdroj:	SN Comprehensive Clinical Medicine. 2:173-180
ISSN:	2523-8973
DOI:	10.1007/s42399-019-00203-0
Popis:	There are few data available on the prevalence of hyperuricemia and its possible association with cardiovascular diseases among the very elderly population. The main part of this study enrolled 320 very elderly hospitalized patients (aged 86.4 ± 5.0 years; females, 78.1%; males, 21.9%) with coronary artery disease (CAD) and arterial hypertension (AH). The second part of the study involved 48 patients younger than 60 years, who were hospitalized with CAD diagnosis for coronary angiography study. Patients with gout were excluded from analysis. Hyperuricemia was defined as serum uric acid (SUA) more than 340 μmol/l in women and 420 μmol/l in men. Elevated serum uric acid (SUA) levels were detected in 37.4% of 320 elderly patients. Hyperuricemia was significantly more common in women (in 41.5% of cases) than in men (in 25%) (p = 0.02). In the group of very elderly patients, there was a clear correlation between hyperuricemia and clinically significant chronic heart failure (OR = 5.0; 95% CI = 2.4–10.7; p
Databáze:	OpenAIRE
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