Synthesis of axially dissymmetric biphenylbisphosphine ligands, bimops and asymmetric hydrogenations of .BETA.-keto ester and .ALPHA.,.BETA.-unsaturated carboxylic acid catalyzed by their ruthenium (II) complexes

Autor:	Naoko Yamamoto, Kazuo Achiwa, Toshiaki Morimoto, Masanao Murata
Rok vydání:	1991
Předmět:	chemistry.chemical_classification Chemistry Carboxylic acid Asymmetric hydrogenation chemistry.chemical_element Tiglic acid General Chemistry General Medicine Medicinal chemistry Catalysis Ruthenium chemistry.chemical_compound Drug Discovery Organic chemistry
Zdroj:	Chemical and Pharmaceutical Bulletin. 39:1085-1087
ISSN:	1347-5223 0009-2363
Popis:	Axially dissymmetric biphenylbisphosphine ligands, BIMOP (1a) and p-MeO-BIMOP (1b) have been newly designed and prepared. The ruthenium (II) complexes of (R)-1a and 1b proved to be excellent catalysts in asymmetric hydrogenations of methyl 3-oxobutanoate and tiglic acid affording (R)-methyl 3-hydroxybutanoate of 95-99 % ee and (R)-2-methylbutyric acid of 86-91 % ee, respectively.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ca907acf5ff60c1850200f79533db67a https://doi.org/10.1248/cpb.39.1085 Zobrazit plný text záznamu