Synthesis of axially dissymmetric biphenylbisphosphine ligands, bimops and asymmetric hydrogenations of .BETA.-keto ester and .ALPHA.,.BETA.-unsaturated carboxylic acid catalyzed by their ruthenium (II) complexes
Autor: | Naoko Yamamoto, Kazuo Achiwa, Toshiaki Morimoto, Masanao Murata |
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Rok vydání: | 1991 |
Předmět: | |
Zdroj: | Chemical and Pharmaceutical Bulletin. 39:1085-1087 |
ISSN: | 1347-5223 0009-2363 |
Popis: | Axially dissymmetric biphenylbisphosphine ligands, BIMOP (1a) and p-MeO-BIMOP (1b) have been newly designed and prepared. The ruthenium (II) complexes of (R)-1a and 1b proved to be excellent catalysts in asymmetric hydrogenations of methyl 3-oxobutanoate and tiglic acid affording (R)-methyl 3-hydroxybutanoate of 95-99 % ee and (R)-2-methylbutyric acid of 86-91 % ee, respectively. |
Databáze: | OpenAIRE |
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