The non-neurogenic catecholamine response of the fetal adrenal to hypoxia is dependent on activation of voltage sensitive Ca2+ channels
| Autor: | Michael Brenton Adams, Isabella Caroline McMillen, Giuseppe Simonetta |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Fetus
medicine.medical_specialty Bicarbonate Hypoxia (medical) Biology chemistry.chemical_compound medicine.anatomical_structure Endocrinology Developmental Neuroscience chemistry Nifedipine Internal medicine medicine Catecholamine Hexamethonium medicine.symptom Adrenal medulla Perfusion Developmental Biology medicine.drug |
| Zdroj: | Developmental Brain Research. 94:182-189 |
| ISSN: | 0165-3806 |
| DOI: | 10.1016/s0165-3806(96)80010-1 |
| Popis: | We have investigated the cellular mechanisms underlying the catecholamine response of the fetal sheep adrenal to hypoxia before and after the development of adrenal innervation. Adrenals were collected before (80–100 days gestation: n = 7) and after (135–146 days gestation: n = 10) development of innervation and retrogradely perfused with oxygenated Krebs bicarbonate buffer in vitro via the renal vein. Adrenal hypoxia was induced by perfusion with hypoxic Krebs buffer (pO2 = 46.7 ± 2.4 mm Hg) for 30 min periods in the presence and absence of hexamethonium (500 μM), Ca2+ (2.5 mM), nifedipine (1 μM) and KCl (10 mM). Hypoxia stimulated an increase (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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