| Popis: |
Alkylation of β-cyclodextrin hydroxyl functions with different substituents results in derivatives having a drastically increased aqueous solubility. Such derivatives were tested by the ‘solubility method’ for their solubilizing properties in combination with hydrocortisone, diazepam, digitoxin and indomethacin. The derivatives preserve the complexing properties of the starting compound. In contrast to β-cyclodextrin, no complexes precipitating from the solutions are formed by the derivatives. Because of this changed solubility of the formed complexes as well as by the high water solubility of the derivatives, it is possible to use them for the solubilization of different pharmaceuticals. In addition, a stabilizing effect of a derivative on aqueous solutions of indomethacin could be shown. |
