Erythrocyte Chimerism and Acquired Immunologic Tolerance

Autor:	W. E. C. Wilson, David W. Talmage
Rok vydání:	1965
Předmět:	Immunology Immunology and Allergy
Zdroj:	The Journal of Immunology. 94:150-156
ISSN:	1550-6606 0022-1767
DOI:	10.4049/jimmunol.94.1.150
Popis:	Summary DBA/2 and C57BL/6 mice were injected with adult B6D2F1 spleen and bone marrow cells in the neonatal period and, after maturation, were grafted with skin from the opposite parent strain. A fluorescein-conjugated rabbit anti-mouse globulin demonstrated isoantibody, specific for B6D2F1 antigens, bound to a small proportion of erythrocytes of 53 of 54 mice that had retained their skin grafts for a minimum of 100 days. The observations indicate that erythrocyte chimerism accompanies immunologic tolerance acquired after injection of newborn mice with viable hematopoietic cells.
Databáze:	OpenAIRE
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