| Popis: |
Dopamine pathways from the midbrain to the striatum control the operations of the basal ganglia, which regulate movement and, perhaps, thought through parallel cortico-striato-pallidothalamo-cortical pathways. Dopamine deficiency in Parkinson's disease leads to loss of normal movement and, perhaps, cognitive deficits of frontal lobe type. Dopamine excess may cause abnormal involuntary movements such as chorea, dystonia and tics, and may even contribute to thought disorders. The normal operation of the basal ganglia, controlled by dopamine, may be the orderly and rational sequencing of the individual components of motor and cognitive plans. |
