Formulation of Fast Disintegrating Tablet Paracetamol Employing Selected Super-disintegrant
| Autor: | Laurensia Nina Irawati, Eva Monica, Devi Rusvita Khoirul Nisah, Rollando Rollando, Rehmadanta Sitepu, Sinta Dwi Larasati Listio |
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| Rok vydání: | 2020 |
| Předmět: |
Chromatography
Design–Expert Materials science Granule (cell biology) 02 engineering and technology 021001 nanoscience & nanotechnology Friability Absorption ratio 030226 pharmacology & pharmacy Dosage form Angle of repose 03 medical and health sciences 0302 clinical medicine medicine General Pharmacology Toxicology and Pharmaceutics 0210 nano-technology Potato starch Xanthan gum medicine.drug |
| Zdroj: | International Journal of Research in Pharmaceutical Sciences. 11:4323-4333 |
| ISSN: | 0975-7538 |
| DOI: | 10.26452/ijrps.v11i3.2648 |
| Popis: | The objective of this research was to investigate paracetamol FDT formula with potato starch and xanthan gum or glycine or ac di sol combination that can produce the best tablet quality. The tablets were prepared by direct compression technique. Superdisintegrant such as Glycine, Ac di sol, Xanthan Gum, and Potato Starch Extract was optimized as 1-19 % on the basis of least disintegration time. Binders such as HPMC were optimized along with optimized superdisintegrant concentration. 3,5% HPMC was selected as optimum binder concentration on the basis of least disintegration time. Granule parameters included in the analysis were flowability, angle of repose, Carr’s index, Hausner’s ratio, and loss on drying (LOD). Tablet parameters included in the analysis were hardness, friability, disintegration time, dissolution, wetting time, and absorption ratio. The result was analyzed by Design Expert 11.1.0.1 program to decide the combination of superdisintegrant that can provide the best tablet qualities. The result showed that potato starch 15.162% and xanthan gum 4,838%, potato starch 15,050% and glycine 4,950%, and potato starch 18.390% and ac di sol 1.610%. Combination of superdisintegrant that can provide the best tablet qualities. It was concluded that, by employing commonly available pharmaceutical excipients such as superdisintegrants, hydrophilic and swellable excipients and proper filler, a fast disintegrating tablet of Paracetamol in tablet dosage form, were formulated successfully with desired characteristics. |
| Databáze: | OpenAIRE |
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