| Popis: |
Cancer is an unsolved clinical problem and a challenge for the current medical science given the limitations of conventional therapies. Systemic therapy presents serious drawbacks and to overcome them, several strategies using delivery systems are being developed such as bionanocomposites. This system is stable in biological fluids and is a promising approach to provide controlled release of therapeutics for in situ therapy of tumors, decreasing side effects. Thus, to successfully develop bionanocomposites it is crucial to choose the right components of the system and to study interactions between polymers and drugs with multiscale computational methods. In this chapter, our main interest will be on bionanocomposites for in situ drug delivery, their efficacy and impact on cancer therapy, and how to select the right polymer and how to study polymeric-drug interactions, in silico. |
