Hairy Cell Leukemia: Residual Splenic Disease After Successfulα2b-Interferon Therapy
| Autor: | Christos Kittas, Phaedon Fessas, Dimitrios Loukopoulos, Panos Panayiotidis, Viki A. Boussiotis, Chrisanthi Mitsoulis-Mentzikoff, Gerassimos A. Pangalis |
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| Rok vydání: | 1992 |
| Předmět: |
White pulp
Cancer Research Pathology medicine.medical_specialty business.industry medicine.medical_treatment Splenectomy Spleen Hematology medicine.disease Peripheral blood mononuclear cell medicine.anatomical_structure Oncology medicine Red pulp Hairy Cell Hairy cell leukemia Splenic disease business |
| Zdroj: | Leukemia & Lymphoma. 6:145-153 |
| ISSN: | 1029-2403 1042-8194 |
| DOI: | 10.3109/10428199209064888 |
| Popis: | Splenectomy with liver biopsies were performed in six hairy cell leukemia patients in whom complete remission was documented after 12 months of α2b-interferon (α2b-IFN) daily administration. Interferon was discontinued the day before splenectomy. The average spleen weight was 383 g, with evidence of red pulp infiltration by hairy cells in all patients with a parallel reconstitution of the white pulp. On splenic imprint preparations mononuclear cells, with features of hairy cells, were identifiable in every case. Study of frozen splenic sections by the alkaline anti-alkaline phosphatase immunohistochemical method revealed a strong HC2 antibody positivity in the red pulp, confirming the hairy cell nature of the red pulp mononuclear infiltration. In addition on imprint preparation acid phosphatase resistant to tartrate (TRAP) positive cells were easily found in all cases. No liver hairy cell infiltration could be found. One month after splenectomy their hematological counts were corrected to absolute normal ... |
| Databáze: | OpenAIRE |
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