The Wittig and Related Reactions in Natural Product Synthesis

Autor:	Kyriacos C. Nicolaou, Janet L. Gunzner, Michael W. Härter, Alan Nadin
Rok vydání:	1997
Předmět:	chemistry.chemical_compound Natural product Polymer science chemistry Organic Chemistry Wittig reaction Total synthesis Organic chemistry Organic synthesis General Chemistry Physical and Theoretical Chemistry Chemical synthesis Organic molecules
Zdroj:	Liebigs Annalen. 1997:1283-1301
ISSN:	1099-0690 0947-3440
DOI:	10.1002/jlac.199719970704
Popis:	Originally reported in Liebigs Annalen in 1953 (then called Justus Liebigs Annalen der Chemie), the Wittig reaction has evolved to include the Horner–Wittig and Horner–Wadsworth–Emmons reactions and several other variations. Today, these reactions constitute some of the most powerful processes for the construction of carbon–carbon bond frameworks, facilitating the chemical synthesis of myriads of organic molecules both in research laboratories and industrial settings. The Wittig and related reactions were proven particularly useful in the field of total synthesis, where they enabled the construction of highly complex structures and had a significant impact in shaping the art to its present state of sophistication. In this article the authors focus, after a brief introduction, on total syntheses from their own laboratories that employ such processes. These examples, together with the numerous others adorning the chemical literature, illustrate amply the importance of the Wittig and related reactions and point to their continuing prominence in organic synthesis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ca46b2e496611ee2849615aa8f9b6416 https://doi.org/10.1002/jlac.199719970704 Zobrazit plný text záznamu Plný text