Genetic and functional diversity of primary auditory afferents
| Autor: | Haohao Wu, Jérôme Bourien, Jean-Luc Puel, Francois Lallemend, Charles Petitpré, Artem Diuba |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Neuron type Physiology Information processing Biology 03 medical and health sciences Functional diversity 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Physiology (medical) Afferent otorhinolaryngologic diseases medicine Identification (biology) sense organs Brainstem Neuroscience 030217 neurology & neurosurgery Cochlea Spiral ganglion |
| Zdroj: | Current Opinion in Physiology. 18:85-94 |
| ISSN: | 2468-8673 |
| DOI: | 10.1016/j.cophys.2020.09.011 |
| Popis: | Type I spiral ganglion neurons (I-SGNs) of the mammalian cochlea convey all acoustic information from the sensory hair cells to second order neurons in the brainstem. Despite evidence supporting physiological diversity of I-SGNs and of its importance for encoding the various features of sounds, knowledge of their molecular diversity is only emerging. In this review, we outline the recent efforts in the identification of mammalian I-SGN types and summarize how genetic and anatomical features of each individual neuron type relate to functional aspects that characterize sound information processing in the primary auditory afferent system. |
| Databáze: | OpenAIRE |
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