ChemInform Abstract: Facile Synthesis of (S)-β-Hydroxy-β-trichloromethylated Aromatic Ketones by the Regioselective Ring Cleavage of Chiral β- Trichloromethyl-β-propiolactone under the Friedel-Crafts Conditions
| Autor: | Tamotsu Fujisawa, Kenji Fujimoto, Makoto Shimizu, E. G. J. Staring, Takatoshi Ito, Hans Wynberg |
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| Rok vydání: | 2010 |
| Předmět: |
inorganic chemicals
Natural product organic chemicals Synthon Regioselectivity General Medicine Cleavage (embryo) Ring (chemistry) Medicinal chemistry chemistry.chemical_compound chemistry health occupations polycyclic compounds Moiety heterocyclic compounds Lewis acids and bases Friedel–Crafts reaction |
| Zdroj: | ChemInform. 28 |
| ISSN: | 0931-7597 |
| DOI: | 10.1002/chin.199725076 |
| Popis: | The reaction of enantiomerically pure beta-trichloromethyl-beta-propiolactone (1) as a chiral building block with an aromatic compound in the presence of Lewis acid provided an acylated product with a chiral trichloromethyl carbinol moiety. The acylated product was used as an effective chiral synthon for natural product synthesis such as enalapril of ACE inhibitor. (C) 1997 Elsevier Science Ltd. |
| Databáze: | OpenAIRE |
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