| Autor: |
Chao Cheng, Peisheng Zhang, Shaofeng Yan, Brian T. Malik, Mary Jo Turk, Tamer B. Shabaneh, Aaron R. Hawkes, Yanding Zhao, Yina H. Huang, Jichang Han, Aleksey K. Molodtsov, Christina V. Angeles, Jennifer L. Vella, Fred W. Kolling, Kathryn A. Lewis, Nikhil Khatwani |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
SSRN Electronic Journal. |
| ISSN: |
1556-5068 |
| DOI: |
10.2139/ssrn.3657537 |
| Popis: |
While immune responses against primary tumors are critically important, T cells must also be capable of functioning at sites where cancers metastasize. Here we investigated how resident memory (TRM) and circulating memory (TCIRCM) CD8 T cells potentiate immunity to cancer in diverse tissue microenvironments. Based on a mouse model of immunity to melanoma with associated autoimmune vitiligo, we show that tumor-specific memory T cells are capable of forming a widespread network of transcriptionally distinct subsets, throughout lymphoid tissues and visceral organs. Among these, we discovered a population of TRM cells that reside durably within LNs, where they protect against invading melanoma cells. These LN-resident memory (LN TRM) cells adopt a transcriptional program that is distinct from TRM cells in other tissues, and which uniquely predicts survival in melanoma patients with regional LN metastases. This work reveals a novel role for TRM cells in durable immunity to cancer at crucial sites of metastasis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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