Regulation of mTORC1 by the Rag GTPases

Autor: Tshering D. Lama-Sherpa, Mi-Hyeon Jeong, Jenna L. Jewell
Rok vydání: 2023
Předmět:
Zdroj: Biochemical Society Transactions. 51:655-664
ISSN: 1470-8752
0300-5127
DOI: 10.1042/bst20210038
Popis: The Rag GTPases are an evolutionarily conserved family that play a crucial role in amino acid sensing by the mammalian target of rapamycin complex 1 (mTORC1). mTORC1 is often referred to as the master regulator of cell growth. mTORC1 hyperactivation is observed in multiple diseases such as cancer, obesity, metabolic disorders, and neurodegeneration. The Rag GTPases sense amino acid levels and form heterodimers, where RagA or RagB binds to RagC or RagD, to recruit mTORC1 to the lysosome where it becomes activated. Here, we review amino acid signaling to mTORC1 through the Rag GTPases.
Databáze: OpenAIRE