Allopurinol in addition to 5-aminosalicylic acid based drugs for the maintenance treatment of ulcerative colitis

Autor:	Robert Löfberg, A Nilsson, Magnus Ström, Lars Lööf, Åke Danielsson, C.-H. Florén, Rolf Hultcrantz, Gunnar Järnerot, O. Broström, Anders Kilander
Rok vydání:	2000
Předmět:	medicine.medical_specialty Chemotherapy Aminosalicylic acid Hepatology business.industry medicine.medical_treatment Gastroenterology Allopurinol medicine.disease Placebo Ulcerative colitis law.invention Surgery chemistry.chemical_compound Pharmacotherapy chemistry Randomized controlled trial law Internal medicine medicine Pharmacology (medical) Colitis business medicine.drug
Zdroj:	Alimentary Pharmacology & Therapeutics. 14:1159-1162
ISSN:	0269-2813
DOI:	10.1046/j.1365-2036.2000.00821.x
Popis:	Background: To investigate the value of combined treatment with allopurinol and 5-aminosalicylic (5-ASA) based drugs as maintenance treatment for ulcerative colitis (UC). Methods: 199 patients with UC in remission but with active disease during the preceding 3 years were included. Allopurinol 100 mg twice daily or placebo was added to the 5-ASA based maintenance treatment. Clinical and endoscopic follow up was performed after 1, 6 and 12 months. Results: Intention-to-treat analysis after 6 and 12 months showed similar results in both groups. A log-rank test showed that 77% in the allopurinol compared to 59% in the placebo group were still in remission after 6 months (P = 0.0083) and 62% and 53% after 12 months, respectively (P = 0.0936). This was mainly due to a higher than expected number of relapses during the first 3 months in the placebo group. After the first 3 months, the rate of relapse in each group was similar. Conclusions: It appears possible that allopurinol in combination with 5-ASA is better than 5-ASA alone for a 6-month, but not a 12-month period. This has to be verified in further dose-ranging studies.
Databáze:	OpenAIRE
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