Evaluation of tetraphenyl-2,3-dihydroxychlorins as potential photosensitizers

Autor:	David Dolphin, Jill K. MacAlpine, Ron Boch
Rok vydání:	2002
Předmět:	Chemistry medicine.medical_treatment In vitro cytotoxicity Lethal dose medicine Photodynamic therapy General Chemistry Cytotoxicity Photochemistry Nuclear chemistry
Zdroj:	Journal of Porphyrins and Phthalocyanines. :146-155
ISSN:	1099-1409 1088-4246
Popis:	A series of β,β-dihydroxychlorins derived from meso-tetraphenylporphyrins (TPPs) have been synthesized. Their in vitro cytotoxicity has been measured and compared to BPDMA (verteporfin). Under the assay conditions BPDMA had an LD 50 (lethal dose to kill 50% of cells) value of 0.007 μM (5 ng/mL). The LD 50 values for the TPP derivatives varied from 1.7 × 10-2 to 9.9 μM depending upon the substituents and their position on the phenyl groups. One example of the dihydroxychlorin prepared from unsubstituted 5,15-diphenylporphyrin was examined and this exhibited an LD 50 of 2.4 × 10-3 μ M !
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ca1eb3c19acdfddb80a01c29d698f78c https://doi.org/10.1142/s1088424602000191 Zobrazit plný text záznamu