Nano-Sized MIL-100(Fe) as a Carrier Material for Nitidine Chloride Reduces Toxicity and Enhances Anticancer Effects In Vitro
| Autor: | Jian Wu, AiQing Ma, LiQing Fang, JiaRui Bi, YuCheng Guan, Yu Zheng |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Polymers and Plastics
Chemistry Scanning electron microscope Liver cell Infrared spectroscopy 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Bioavailability Dynamic light scattering Toxicity Materials Chemistry MTT assay 0210 nano-technology Cytotoxicity Nuclear chemistry |
| Zdroj: | Journal of Inorganic and Organometallic Polymers and Materials. 30:3388-3395 |
| ISSN: | 1574-1451 1574-1443 |
| Popis: | Nitidine chloride (NC) is a natural alkaloid and has strong antitumor activity. However, its clinical application is limited due to the observed non-specific toxicity and low bioavailability. In this study, we synthesized nanoscale metal–organic frameworks MIL-100(Fe), which was used as a nanocarrier to deliver NC. MIL-100(Fe) was characterized by X-ray diffraction (XRD), Fourier transform infrared spectrometer (FT-IR), Brunauer–Emmett–Teller (BET), dynamic light scattering (DLS), and scanning electron microscopy (SEM). NC was encapsulated in MIL-100(Fe) with a high loading capacity of 33.43 wt%. It shown that NC has progressive releasing behavior with 68% in 4 days under phosphate-buffered saline. The in vitro cytotoxicity of free NC and NC@MIL-100(Fe) were investigated by the MTT assay using the healthy liver cell line (LO2) and a liver cancer cell line (HepG2). Interestingly, NC@MIL-100(Fe) exhibited low toxicity on LO2 cells and high cytotoxicity in HepG2 cells compared to free NC. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink