Lack of evidence for progression of atherosclerosis during puberty in type 1 diabetes
| Autor: | Alexia S Peña, Jemma Anderson, Jennifer Harrington, Craig Hirte, Jennifer J Couper, Roger Gent, Oana Maftei |
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| Rok vydání: | 2015 |
| Předmět: |
Research design
medicine.medical_specialty Endocrinology Diabetes and Metabolism Cardiovascular risk factors 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Carotid imt 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Diabetes mellitus Internal Medicine Medicine cardiovascular diseases Prospective cohort study Type 1 diabetes business.industry Cholesterol Leptin medicine.disease Endocrinology chemistry Pediatrics Perinatology and Child Health cardiovascular system business |
| Zdroj: | Pediatric Diabetes. 17:199-205 |
| ISSN: | 1399-543X |
| DOI: | 10.1111/pedi.12265 |
| Popis: | Objectives Children with type 1 diabetes have early changes in vascular structure with increased aortic intima–media thickness (aIMT) or carotid IMT (cIMT). aIMT may be an earlier, more sensitive marker; however, longitudinal data in type 1 diabetes are lacking. This study will aim to evaluate changes in vascular structure (aIMT and cIMT) over 2 yr during puberty in children with type 1 diabetes and compare them with those in healthy children. Research design and methods A total of 110 children (aged 10–18 yr, 55 males) participated in a prospective cohort study, including 77 children with type 1 diabetes and 33 age- and sex-matched healthy children. Ultrasound assessments of aIMT and cIMT; and clinical and biochemical data were collected at baseline and 2 yr later. Results Mean and maximal aIMT or cIMT did not worsen over time in children with type 1 diabetes compared with healthy children. Longer duration of diabetes related to an increase in aIMT. Improvement in HDL cholesterol and leptin related to a decrease in aIMT. Higher baseline IMT related to an improvement in IMT in children with type 1 diabetes (mean and maximal aIMT: β = −0.52, p |
| Databáze: | OpenAIRE |
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