| Autor: |
Jingyuan Wang, Ya-Peng Li, Han-Yu Zhu, Chao Fang, Wai-Ou Zhao |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Chinese Journal of Analytical Chemistry. 48:e20149-e20157 |
| ISSN: |
1872-2040 |
| DOI: |
10.1016/s1872-2040(20)60066-4 |
| Popis: |
Oxidative stress is one of the major factors involved in pathogenesis of atherosclerosis. Here, a smart dual-function drug delivery system (DDS) that neutralized the plaques through its reaction with the oxidative microenvironment was fabricated. Micelles were obtained from the graft copolymer of serotonin hydrochloride, polyethylene glycol, p (itaconic acid) and aminophenylboronic-acid-linked rutin. Fluorescence carbon quantum dots (CDs) were attached to the surface of the micelles to provide dual functionality of precise treatment and diagnosis. DDS was simultaneously served as a stimuli-responsive drug delivery carrier and as a probe to detect plaques. In vitro experiments indicated that these “smart” nanoparticles could efficiently target macrophages and provide accurate imaging. At the same time, their “smart” responses to H2O2 solved the problem of sudden drug release, which could significantly improve therapeutic effect of the delivered drug. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect