DNA TYPING FOR HLA-DPB1-ALLELES IN GERMAN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS USING THE POLYMERASE CHAIN REACTION AND DIG-ddUTP-LABELLED OLIGONUCLEOTIDE PROBES

Autor:	S. Mikschl, E. Keller, Maria P. Bettinotti, C. Gawron, G. Brünnler, Helmuth R. G. Deicher, K. Hartung, Ekkehard D. Albert, Z. Yao, Christian Paul
Rok vydání:	1993
Předmět:	Linkage disequilibrium Lupus erythematosus HLA-DPB1 Immunology Haplotype Locus (genetics) Biology medicine.disease law.invention immune system diseases law Genetics Genetic predisposition medicine Allele skin and connective tissue diseases Polymerase chain reaction
Zdroj:	European Journal of Immunogenetics. 20:259-266
ISSN:	1365-2370 0960-7420
DOI:	10.1111/j.1744-313x.1993.tb00141.x
Popis:	SUMMARY Genomic DNA of 178 German Caucasian patients with systemic lupus erythematosus are studied for HLA-DP locus by using PCR and DIG-ddUTP-labelled oligonucleotide probes. A significant increase of DPB1*0101 is observed in SLE patients compared with healthy controls (χ < 2 < = 15.27, p.c.
Databáze:	OpenAIRE
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