Ultrasonic promoted synthesis of novel s -triazine-Schiff base derivatives; molecular structure, spectroscopic studies and their preliminary anti-proliferative activities
| Autor: | Hazem A. Ghabbour, Saied M. Soliman, Fernando Albericio, Yasser A. Elnakady, Talal Abdulaziz Mohaya, Ayman El-Faham, Mohammed Rafiq H. Siddiqui |
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| Rok vydání: | 2016 |
| Předmět: |
chemistry.chemical_classification
Schiff base Base (chemistry) 010405 organic chemistry Organic Chemistry Substituent 010402 general chemistry Ring (chemistry) 01 natural sciences Combinatorial chemistry 0104 chemical sciences Analytical Chemistry Inorganic Chemistry chemistry.chemical_compound chemistry Elemental analysis X-ray crystallography Organic chemistry Molecule Spectroscopy Triazine |
| Zdroj: | Journal of Molecular Structure. 1125:121-135 |
| ISSN: | 0022-2860 |
| DOI: | 10.1016/j.molstruc.2016.06.061 |
| Popis: | Novel series of s-triazine-Schiff base derivatives were synthesized employing ultrasonic irradiation and characterized by NMR (1H and 13C), FT-IR, and elemental analysis. The use of ultrasonic irradiation has allowed the preparation of the target products with better yields in shorter reaction time and excellent purities compared to the conventional heating. X-ray single crystal diffraction experiments verified the molecular structure of four from the new prepared s-triaizne-Schiff base derivatives. The molecular structures of the studied compounds are computerized using DFT/B3LYP method. The effects of substituent at the triazine and phenyl ring on the electronic and spectroscopic properties of the studied compounds were also investigated. The natural atomic charges showed that pipridino-s-triazine derivatives are richer in electrons than those having morpholino derivatives. The anti-proliferative effects for the prepared compounds were tested against three different cancer cell lines. |
| Databáze: | OpenAIRE |
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