| Autor: |
Lucy Chan, T. W. Hui, T. J. Yao, M. Shahnaz Hasan, Michael G. Irwin, V. M. Yuen, G. L. Wong, Ina Ismiarti Shariffuddin |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
Anaesthesia. 67:1210-1216 |
| ISSN: |
0003-2409 |
| DOI: |
10.1111/j.1365-2044.2012.07309.x |
| Popis: |
We compared sedation levels in children following administration of intranasal dexmedetomidine. One hundred and sixteen children aged between 1 and 8 years were enrolled in this prospective, randomised trial. Children were assigned to receive either intranasal dexmedetomidine 1 μg.kg(-1) (Group 1) or 2 μg.kg(-1) (Group 2). Thirty-one (53%) patients from Group 1 and 38 (66%) patients from Group 2 were satisfactorily sedated at the time of anaesthetic induction. Logistic regression showed a significant interaction effect (p=0.049), with the odds ratio between Group 2 over Group 1 estimated as 1.1 (95% CI 0.5-2.7) for the 1-4 year age group, and 10.5 (95% CI 1.4-80.2) for the 5-8 year age group. Both doses produced a similar level of satisfactory sedation in children aged 1-4 years, whereas 2 μg.kg(-1) resulted in a higher proportion of satisfactory sedation in children aged 5-8 years. There were no adverse haemodynamic effects. We conclude that intranasal dexmedetomidine in a premedication dose of 2 μg.kg(-1) resulted in excellent sedation in children. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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