Impact of the Dietary Lipid Matrix on Neurodevelopmental Patterns of the Piglet

Autor: Reeba Jacob, Ryan N. Dilger, Austin T. Mudd, Chron-Si Lai
Rok vydání: 2015
Předmět:
Zdroj: The FASEB Journal. 29
ISSN: 1530-6860
0892-6638
DOI: 10.1096/fasebj.29.1_supplement.754.15
Popis: Using the piglet as a biomedical model, we assessed the impact of dietary fat composition on postnatal neurodevelopment. Two-day old piglets (n=9-10/treatment, 1.5 ± 0.2 kg initial BW) were fed 1 of 4 isocaloric dietary treatments: T1, artificially-reared (AR) control formula; T2, T1 + 45% total dietary fat replaced with pre-digested fat (PDF); T3, T2 + novel lipid blend; T4: sow-reared (SR) control. At conclusion of the 25-d study, pigs were subjected to MRI procedures to assess brain structure. Overall, SR pigs exhibited higher (P < 0.05) BW gain and whole-brain weights compared with AR treatments. Assessment of brain structure revealed volumes of whole brain and specific regions to be higher (P < 0.05) in SR pigs compared with all AR treatments. Diffusion tensor imaging revealed that SR pigs had greater (P < 0.05) average whole-brain fractional anisotropy (FA) values compared with all AR treatments, suggesting differences in the degree of myelination. However, average FA, axial and radial diffusivity v...
Databáze: OpenAIRE
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