Contact sensitization to N-(cyclohexylthio)phthalimide
| Autor: | Johannes Geier, Holger Lessmann, Peter J. Frosch, Axel Schnuch |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Allergy N-(cyclohexylthio)phthalimide viruses Population Dermatology Rubber chemicals Gastroenterology 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Immunology and Allergy heterocyclic compounds education Allergic contact dermatitis Sensitization education.field_of_study business.industry Patch test medicine.disease 030210 environmental & occupational health 3. Good health Surgery enzymes and coenzymes (carbohydrates) medicine.anatomical_structure business Contact dermatitis |
| Zdroj: | Contact Dermatitis. 48:1-6 |
| ISSN: | 0105-1873 |
| DOI: | 10.1034/j.1600-0536.2003.480101.x |
| Popis: | Previous reports revealed relative high sensitization rates to the rubber chemical N-(cyclohexylthio)phthalimide (CTP; CAS-No. 17796-82-6), but the relevance of positive reactions remained unknown. It was discussed whether the test concentration of 1% pet. needed to be changed. The German Contact Dermatitis Research Group (DKG) added CTP in 3 concentrations, i.e. 0.25% pet., 0.5% pet, 1% pet., to the rubber series. From June 1999 to December 2000, 1936 patients in 30 departments of dermatology were tested with CTP. Of the 56 patients with a positive test reaction (2.9%), 52 reacted to CTP 1% pet., 21 to CTP 0.5% pet., and 9 to CTP 0.25% pet. The reaction indices were about the same with all concentrations. 34 patients with a positive reaction to CTP 1% pet. did not react to the lower concentrations. The majority of these reactions are probably false-positive. With CTP 0.25% pet., however, the majority of true allergic reactions to CTP were missed. Analysis of population characteristics and concomitant sensitizations to other rubber chemicals led to the conclusion that a positive reaction to CTP 0.5% pet. was a good indicator of contact allergy to CTP. Thus, the DKG decided to continue patch testing with CTP 0.5% pet. in the rubber series. Manufacturers' information about the use of CTP seem to partly contradict the patients' characteristics seen in this study. So the relevance of positive CTP patch test reactions, and the causative exposures in patients with CTP allergy, still remain to be clarified. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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