PROCESSES OF LIPID PEROXIDATION AND SYSTEM OF ANTIOXIDANT PROTECTION IN THE BLOOD OF THE UMBILICAL CORD OF INFANTS AT CYTOMEGALOVIRUS INFECTION IN PREGNANCY
| Autor: | Nikolay Dorofienko |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Pulmonary and Respiratory Medicine
Pregnancy 030219 obstetrics & reproductive medicine Antioxidant business.industry medicine.medical_treatment Physiology medicine.disease Umbilical cord Cytomegalovirus infection Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine.anatomical_structure chemistry Pediatrics Perinatology and Child Health medicine business 030217 neurology & neurosurgery |
| Zdroj: | Bulletin physiology and pathology of respiration. 1:74-77 |
| ISSN: | 1998-5029 |
| DOI: | 10.12737/article_5c126b6fc9a1d6.28434252 |
| Popis: | The aim of the work is to study the activity of lipoperoxidation processes and antioxidant protection system in the umbilical cord blood of newborns from CMV-seropositive women with exacerbation of infection in the third trimester of pregnancy. Lipid peroxidation activity and antioxidant status in 30 newborns from CMV-seropositive women with exacerbation of infection in the third trimester of pregnancy and in 25 from CMV-seronegative women were studied. Erythrocytes were used to determine the products of oxidative modification of lipids; antioxidant status was evaluated in the blood plasma of the umbilical vein. The content of TBK-active products was determined by fluorometric method, lysophosphatidylcholine by thin-layer chromatography, arachidonic acid by gas-liquid chromatography. Antioxidant status was assessed by α-tocopherol content and superoxide dismutase activity. Registration of optical densities and fluorescence was carried out using a spectrofluorometer. The study found an increase in the content of red blood cells of the umbilical cord of newborns from CMV-seropositive women with an exacerbation of infection in the third trimester of pregnancy of TAC-active products in 2.1 times (p˂0.001), of lysophosphatidylcholine in 1.9 times (p˂0.001) and of arachidonic acid in 1.5 times (p˂0.001). The antioxidant status of umbilical cord blood was characterized by 1.5 times decrease in α-tocopherol (p |
| Databáze: | OpenAIRE |
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