Antioxidants in erythrocytes in aging and dementia
| Autor: | A.C. Poghosyan, Lyudmila A. Tikhonova, Yury G. Kaminsky, E. A. Kosenko |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty Antioxidant biology medicine.medical_treatment Glutathione peroxidase Glutathione reductase General Medicine Glutathione Oxidative phosphorylation medicine.disease_cause General Biochemistry Genetics and Molecular Biology Superoxide dismutase chemistry.chemical_compound Endocrinology chemistry Internal medicine medicine biology.protein Glutathione disulfide Oxidative stress |
| Zdroj: | Biomeditsinskaya Khimiya. 59:443-451 |
| ISSN: | 2310-6905 2310-6972 |
| DOI: | 10.18097/pbmc20135904443 |
| Popis: | Age of patients and brain oxidative stress may contribute to pathogenesis of Alzheimer's disease (AD). Erythrocytes (red blood cells, RBC) are considered as passive “reporter cells” for the oxidative status of the whole organism and are not well studied in AD. The aim of this work was to assess whether the antioxidant status of RBC changes in aging and AD. Blood was taken from AD and non-Alzheimer's dementia patients, aged-matched and younger controls. In vivo antioxidant status was assessed in each of the study subjects by measuring RBC levels of Н О , organic hydroperoxides, glutathione (GSH) and glutathione disulfide (GSSG), activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione S-transferase, and glucose-6-phosphate dehydrogenase. In both aging and dementia, oxidative stress in RBC was shown to increase and to be expressed in elevated concentrations of H O and organic hydroperoxides, decreased the GSH/GSSG ratio and glutathione S-transferase activity. Decreased glutathione peroxidase activity in RBC may be considered as a new peripheral marker for Alzheimer’s disease while alterations of other parameters of oxidative stress reflect age-related events. |
| Databáze: | OpenAIRE |
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