Reaction of substituted o-aminophenols with acylpyruvic acid esters and α-ketoglutaric acid. Antibacterial activity of the products

Autor:	E. B. Babushkina, E. V. Voronina, V. L. Gein, N. V. Shepelina, N. A. Rassudikhina, M. I. Vakhrin
Rok vydání:	2008
Předmět:	Pharmacology Ketoglutaric Acid Chemistry Drug Discovery Pharmacology toxicology Organic chemistry Nuclear magnetic resonance spectroscopy Antibacterial activity Mass spectrometry
Zdroj:	Pharmaceutical Chemistry Journal. 42:529-532
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-009-0175-5
Popis:	Reaction of methyl esters of acylpyruvic acids with substituted o-aminophenols led to 6(7)-substituted 3-acylmethylene-1,4-benzoxazin-2-ones. Reaction of substituted o-aminophenols with α-ketoglutaric acid led to 6-substituted 3-carbonyl-1,4-benzoxazin-2-ones. The structures of the synthesized compounds were confirmed by IR and NMR spectroscopy and mass spectrometry. The antibacterial activity of the compounds was studied.
Databáze:	OpenAIRE
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