| Autor: |
Miller, Melissa B, Hoover, Wynton C, Muhlebach, Marianne Sponer, Zemanick, Edith T, Beckett, Valeria, Campbell, Preston, Baines, Arthur, Popowitch, Elena, Vandalfsen, Jill M, Mayer-Hamblett, Nicole, Goss, Christopher H |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| DOI: |
10.17615/5n23-4346 |
| Popis: |
OBJECTIVE: To evaluate microbiological effectiveness, that is, culture negativity of a non-blinded eradication protocol (Rx) compared with observation (Obs) in clinically stable cystic fibrosis participants with newly positive methicillin resistant Staphylococcusaureus (MRSA) cultures. DESIGN: This non-blinded trial randomised participants ages 4-45 years with first or early (≤2 positive cultures within 3 years) MRSA-positive culture without MRSA-active antibiotics within 4 weeks 1:1 to Rx or Obs. The Rx protocol was: oral trimethoprim-sulfamethoxazole or if sulfa-allergic, minocycline plus oral rifampin; chlorhexidine mouthwash for 2 weeks; nasal mupirocin and chlorhexidine body wipes for 5 days and environmental decontamination for 21 days. The primary end point was MRSA culture status at day 28. RESULTS: Between 1 April 2011 to September 2014, 45 participants (44% female, mean age 11.5 years) were randomised (24 Rx, 21 Obs). At day 28, 82% (n=18/22) of participants in the Rx arm compared with 26% (n=5/19) in the Obs arm were MRSA-negative. Adjusted for interim monitoring, this difference was 52% (95% CI 23% to 80%, p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
