| Autor: |
Metcalf Cje, Andreas Mayer, Downie Ae, Andrea L. Graham |
| Rok vydání: |
2021 |
| Předmět: |
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| DOI: |
10.1101/2021.03.11.434955 |
| Popis: |
Epidemiology and life history are commonly hypothesized to influence host immune strategy, and the pairwise relationships between immune strategy and each factor have been extensively investigated. But the interaction of these two is rarely considered, despite evidence that this interaction might produce emergent effects on optimal immune strategy. Here we investigate the confluence of epidemiology and life history as it affects immune strategy through a demographically-framed model of sensitivity and specificity in parasite recognition and response. We find that variation in several different life history traits associated with both reproduction and longevity alters optimal immune strategies – but the direction and magnitude of these effects depends on how epidemiological risks vary across life. Drawing on published life history data, we also find that our predictions apply across chordate taxa. Our results shed light on the complex interactions shaping immune strategy and may prove valuable in interpreting empirical results in ecoimmunology. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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