Silica-gold nanoshell@graphene: a novel class of plasmonic nanoagents for photothermal cancer therapy
| Autor: | Mohsen Rajaeinejad, Keivan Majidzadeh-A, Mohsen Farokhnezhad, Mahdi Esmaeilzadeh, Shahrokh Iravani, Mahyar Nourian, Hasan Jalaeikhoo |
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| Rok vydání: | 2020 |
| Předmět: |
Materials science
Acoustics and Ultrasonics Graphene business.industry Shell (structure) 02 engineering and technology Photothermal therapy 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences Nanoshell 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials law.invention Core (optical fiber) law Bioheat transfer Optoelectronics Surface plasmon resonance 0210 nano-technology business Plasmon |
| Zdroj: | Journal of Physics D: Applied Physics. 53:405401 |
| ISSN: | 1361-6463 0022-3727 |
| Popis: | In the current work, the optical properties of graphene wrapped gold nanoshells (GGNSs) with silica core for different sizes and geometries are investigated based on effective medium and Gans theories in tumor tissue. In addition, the bioheat transfer equations are used to obtain the temperature distribution in the kidney tumor and its surrounding medium. The localized surface plasmon resonance (LSPR) peak of GGNSs can be easily tuned inside a large region of biological windows by controlling the thicknesses of gold and graphene layers and their aspect ratios for spheroidal nanoshells. Also, we show that oblate spheroidal GGNSs due to high temperature rise are very effective for photothermal cancer therapy. Moreover, the amount of temperature rise for spherical nanoshells increases as the thickness of graphene shell increases, while it is independent of the thickness of graphene shell for spheroidal GNSs. Finally, the regions of tumor tissue with permanent thermal damage are determined by calculating thermal damage in tumor tissue. Our results demonstrate that GGNSs have a high potential for photothermal cancer therapy. |
| Databáze: | OpenAIRE |
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